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DeCS
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Descriptor English:
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Cholesterol Side-Chain Cleavage Enzyme
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Descriptor Spanish:
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Enzima de Desdoblamiento de la Cadena Lateral del Colesterol
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Descriptor Portuguese:
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Enzima de Clivagem da Cadeia Lateral do Colesterol
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Synonyms English:
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CYP11A1
Cholesterol Desmolase
Cholesterol Monooxygenase (Side-Chain-Cleaving)
Cytochrome P-450 CYP11A1
Cytochrome P-450(scc)
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Tree Number:
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D08.244.453.915.212
D08.811.682.690.708.170.915.212
D12.776.422.220.453.915.212
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Definition English:
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A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones. |
History Note English:
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2003 (1975)
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Allowable Qualifiers English:
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Record Number:
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23192
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Unique Identifier:
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D002786
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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